First things first, I've removed Fedora's top panel, and added everything I need from gnome on the bottom panel. I know it gives a more 'Windows' look and feel, but when you are on 9" or 10" screen running at 1024x600, there isn't much room for being pick.

As far as Firefox goes, here are a few things you can do:
1. Remove 'Status bar' and 'Bookmark Bar'. (Under 'View' on the main menu)
2. Install the
Littlefox theme.
3. Customize your toolbars to 'Use small icons'
4. Install
Fastdial add-on, that replaces the functionality of the 'Bookmark Bar' in case you are lazy like me.
5. Install
Tiny Menu, once you do that, move all of the items from your 'Navigation Toolbar' to the Main Menu, and hide the 'Navigation Toolbar' under View.
6. Install
Adblock Plus which will eliminate a lot of junk ads from websites, like cnn.com (see screenshot above).
Enjoy